Novartis Aktie
WKN: 904278 / ISIN: CH0012005267
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13.02.2026 07:14:44
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Press Release: Novartis Vanrafia(R) Phase III -2-
References
1. Novartis. Data on file.
2. Novartis Pharmaceuticals Corporation. Novartis receives FDA accelerated
approval for Vanrafia(R) (atrasentan), the first and only selective
endothelin A receptor antagonist for proteinuria reduction in primary IgA
nephropathy (IgAN). Available at:
https://www.novartis.com/news/media-releases/novartis-receives-fda-accelerated-approval-vanrafia-atrasentan-first-and-only-selective-endothelin-receptor-antagonist-proteinuria-reduction-primary-iga-nephropathy-igan.
Accessed February 2026.
3. ClinicalTrials.gov. NCT04573478. A Phase 3, Randomized, Double-blind,
Placebo-controlled Study of Atrasentan in Patients with IgA Nephropathy
at Risk of Progressive Loss of Renal Function. Available at
https://clinicaltrials.gov/study/NCT04573478. Accessed February 2026.
4. Cheung C, Barratt J. The rapidly changing treatment landscape of IgA
nephropathy. Semin Nephrol. 2025;44:151573.
5. Kwon CS, Daniele P, Forsythe A et al. A systematic literature review of
the epidemiology, health-related quality of life impact, and economic
burden of immunoglobulin a nephropathy. J Health Econ Outcomes Res.
2021;8:36--45.
6. Pitcher D, Braddon F, Hendry B et al. Long-term outcomes in IgAN. Clin J
Am Soc Nephrol. 2023;18:727--8.
7. Mohd R, Mohammad Kazmin NE, Abdul Cader R, et al. Long-term outcome of
immunoglobulin A (IgA) nephropathy: a single center experience. PLoS One.
2021;16:e0249592.
8. National Kidney Foundation. The voice of the patient (2020). Available
at:
https://igan.org/wp-content/uploads/2021/01/VOP_IgAN_12-7-20__FNL.pdf.
Accessed February 2026.
9. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases
Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of
Glomerular Diseases. Kidney Int. 2021;100:S1--276.
10. Barratt J, Kim SG, Inker LA et al. AFFINITY study: 1-year results of
atrasentan in IgAN. J Am Soc Nephrol. 2024;35(Suppl):720. Abstract
FR-P0855.
11. Heerspink HJL, Jardine M, Kohan DE et al. Atrasentan in patients with
IgAN. N Engl J Med. 2025;392:544--54.
12. Heerspink HJL, Jardine M, Kohan DE et al. Study design and baseline
characteristics of ALIGN, a randomized controlled study of atrasentan in
patients with IgAN. Kidney Int Rep. 2024;10:217--26.
13. Kohan DE, Barratt J, Heerspink HJL et al. Targeting the endothelin A
receptor in IgAN. Kidney Int Rep. 2023;8:2198--210.
# # #
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E-mail: media.relations@novartis.com
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(END) Dow Jones Newswires
February 13, 2026 01:15 ET (06:15 GMT)
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