23.01.2008 12:15:00
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Corgenix Medical Says New Study Further Establishes Concept of ''Aspirin Resistance''
Corgenix Medical Corporation (OTCBB:CONX) says a Canadian study
published in the January 18, 2008, online BMJ (British Medical Journal)
further establishes the concept of "aspirin
resistance.” The study showed that patients
who are non responsive to the anti-clotting effects of aspirin are at
much greater risk of heart attack, stroke and blood clots than patients
who are sensitive to aspirin.
"This data confirms once again that over 25
percent of all patients taking aspirin do not respond to the drug,”
said Douglass Simpson, Corgenix’ President
and Chief Executive Officer. "Our
AspirinWorks product is now perfectly positioned to assist the medical
community in quickly, easily and accurately determining the effect of
aspirin in patients.”
The study, entitled "Aspirin ‘resistance’
and risk of cardiovascular morbidity: systematic review and
meta-analysis,” compiled information from
20 studies totaling almost 3,000 patients with cardiovascular disease.
The article hypothesized that based on the available data and with
compliance accurately accounted for, aspirin non response is real and is
clinically relevant, leading to adverse cardiovascular outcomes.
"This is the crucial, potentially life-saving
information that doctors and patients want and need to know,”
explained Corgenix’ Clinical Affairs Director
Gordon Ens. "Now that clinically significant
variability in aspirin effect has been well-established, and patients
can be informed of this possibility, the next logical step is for
researchers to establish standardized protocols for treating patient
populations non-responsive to the effects of aspirin.”
The authors of the BMJ review are at Toronto General Hospital (Toronto,
ON, Canada) and McMaster University (Hamilton, ON, Canada). To access
the full article, go to: http://www.bmj.com/cgi/content/full/bmj.39430.529549.BEv1
The authors concluded that patients who are resistant to aspirin are at
a greater risk of clinically important cardiovascular morbidity and
mortality long term than patients who are sensitive to aspirin. The data
showed:
28 percent of patients who took aspirin do not respond to the drug
Patients identified as "aspirin resistant”
by the study had a fourfold increased risk of a cardiovascular event
(such as heart attack, stroke or blood clot)
A cardiovascular related event occurred in 41 percent of patients
Aspirin resistant patients were six times as likely to die than
aspirin sensitive patients
Aspirin resistant patients did not benefit from other antiplatelet
treatment
The study’s authors strongly advised that "doctors
continue their current practice in prescribing aspirin for chronic
therapy to prevent adverse cardiovascular events as the overall risk
reduction is well reported.” However, the
study also recommended that patients are fully informed about the
possible adverse effects of (non response to) aspirin.
The AspirinWorks test was launched in the United States in June 2007
following FDA 510(k) clearance, and it is now available nationwide
through major medical reference laboratories. The test measures the
effect of aspirin on platelets through direct measurement of thromboxane
production (aspirin’s target). The stickier
the blood platelets, the less impact the aspirin is having.
About AspirinWorks®
The AspirinWorks®
Test Kit is an enzyme-linked immunoassay (ELISA) to determine levels of
11-Dehydro Thromboxane B2 (11dhTxB2)
in human urine, which aids in the qualitative detection of aspirin
effect in apparently healthy individuals post ingestion. The product
received clearance in May 2007 by the U.S. Food and Drug Administration
for in vitro diagnostic use in the United States. Unlike other
platelet aggregation tests, which require freshly drawn blood that must
be evaluated within at least 4 hours, the AspirinWorks®
test requires a urine sample that can easily be obtained in any doctor’s
office.
About Corgenix Medical Corporation
Corgenix is a leader in the development and manufacturing of specialized
diagnostic kits for vascular diseases, immunology disorders, and bone
and joint disorders. Corgenix diagnostic products are commercialized for
use in clinical laboratories throughout the world. The company currently
sells over 52 diagnostic products through a global distribution. More
information is available at www.corgenix.com.
Statements in this press release that are not strictly historical
facts are "forward looking”
statements (identified by the words "believe”,
"estimate”, "project”,
"expect” or
similar expressions) within the meaning of the Private Securities
Litigation Reform Act of 1995. These statements inherently involve risks
and uncertainties that could cause actual results to differ materially
from the forward-looking statements. Factors that would cause or
contribute to such differences include, but are not limited to,
continued acceptance of the Company’s
products and services in the marketplace, competitive factors, changes
in the regulatory environment, and other risks detailed in the Company’s
periodic report filings with the Securities and Exchange Commission. The
statements in this press release are made as of today, based upon
information currently known to management, and the Company does not
undertake any obligation to publicly update or revise any
forward-looking statements.
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